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J Health Info Stat > Volume 36(1); 2011 > Article
J Health Info Stat 2011;36(1):63-76.
근로자 건강보호목표수준 제안을 위한 이소프렌의 용량-반응 평가 적용연구
김현지 , 신동천 , 임영욱 , 양지연 , 이용진
Dose-Response Assessment of Isoprene for Occupational Health Protection Target Level
Hyun Ji Kim , Dong Chun Shin , Young Wook Lim , Ji Yeon Yang , Yong Jin Lee
ABSTRACT
Objectives:
We investigated the method of application of dose-response assessment of domestic industry to present occupational health protection target level.
Methods:
Melnick`s study data and NTP (National Toxicology Program) data using data, deterministic methods and probabilistic approaches were compared.
Results:
As a result of the dose-response assessment based on Melnick`s data and NTP data, RfC (Reference Concentration) was calculated as 1.3 ppm (determined by the NTP data). So in this paper they were determined at the health protection target level of 1.3 ppm. Final results according to the type of data, the dose-response assessment method are determined.
Conclusions:
Dose-response assessment based on Isoprene revealed that most important thing is toxicity endpoint to suggest health protection target level by utilizing dose-response assessment to the domestic workplace.
Key words: Isoprene, Occupational health protection target Level, Dose-response assessment
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